Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.

Bryant, Josephine M and Grogono, Dorothy M and Rodriguez-Rincon, Daniela and Everall, Isobel and Brown, Karen P and Moreno, Pablo and Verma, Deepshikha and Hill, Emily and Drijkoningen, Judith and Gilligan, Peter and Esther, Charles R and Noone, Peadar G and Giddings, Olivia and Bell, Scott C and Thomson, Rachel and Wainwright, Claire E and Coulter, Chris and Pandey, Sushil and Wood, Michelle E and Stockwell, Rebecca E and Ramsay, Kay A and Sherrard, Laura J and Kidd, Timothy J and Jabbour, Nassib and Johnson, Graham R and Knibbs, Luke D and Morawska, Lidia and Sly, Peter D and Jones, Andrew and Bilton, Diana and Laurenson, Ian and Ruddy, Michael and Bourke, Stephen and Bowler, Ian C J W and Chapman, Stephen J and Clayton, Andrew and Cullen, Mairi and Dempsey, Owen and Denton, Miles and Desai, Maya and Drew, Richard J and Edenborough, Frank and Evans, Jason and Folb, Jonathan and Daniels, Thomas and Humphrey, Helen and Isalska, Barbara and Jensen-Fangel, Søren and Jönsson, Bodil and Jones, Andrew M and Katzenstein, Terese L and Lillebaek, Troels and MacGregor, Gordon and Mayell, Sarah and Millar, Michael and Modha, Deborah and Nash, Edward F and O'Brien, Christopher and O'Brien, Deirdre and Ohri, Chandra and Pao, Caroline S and Peckham, Daniel and Perrin, Felicity and Perry, Audrey and Pressler, Tania and Prtak, Laura and Qvist, Tavs and Robb, Ali and Rodgers, Helen and Schaffer, Kirsten and Shafi, Nadia and van Ingen, Jakko and Walshaw, Martin and Watson, Danie and West, Noreen and Whitehouse, Joanna L and Haworth, Charles S and Harris, Simon R and Ordway, Diane and Parkhill, Julian and Floto, R Andres (2016) Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science (New York, N.Y.), 354 (6313). pp. 751-757. ISSN 1095-9203.

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Official URL: http://science.sciencemag.org/content/354/6313/751...


Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

Item Type: Article
Subjects: WC Communicabable diseases > WC680 Tropical medicine
WF Respiratory system. Respiratory medicine
Divisions: Planned IP Care > Respiratory Medicine
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Depositing User: Preeti Puligari
Date Deposited: 30 Mar 2017 10:05
Last Modified: 30 Mar 2017 10:05
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1299

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