Memory, attention and fluency deficits in COPD may be a specific form of cognitive impairment.

Morris, Charlotte and Mitchell, James W and Moorey, Hannah and Younan, Helen-Cara and Tadros, George and Turner, Alice M (2019) Memory, attention and fluency deficits in COPD may be a specific form of cognitive impairment. ERJ open research, 5 (2). ISSN 2312-0541. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65368...

Abstract

There is increasing evidence demonstrating an association between chronic obstructive pulmonary disease (COPD) and cognitive impairment. We present a narrative review of published studies on the subject and a cross-sectional study investigating domain-specific cognitive impairment in people with COPD compared to people with known Alzheimer's dementia, and controls without known COPD or cognitive impairment. The aim of the study was to compare prevalence and pattern of cognitive impairment between the three groups using the Addenbrooke's Cognitive Examination (ACE)-III tool. A total of 89 participants were recruited (44 with COPD, 17 with Alzheimer's and 28 controls). Patients with COPD had significantly lower total ACE-III scores than controls (p<0.001). When comparing the COPD group to the known Alzheimer's dementia group, overall ACE-III scores were significantly lower in the Alzheimer's dementia group than the COPD group (p=0.019). The domain-specific scores for attention (p<0.004), memory (p<0.004) and fluency (p<0.001) were significantly lower in the Alzheimer's dementia group than the COPD group. Our result suggest that the COPD group were significantly more likely to have cognitive impairment than the healthy control group. This was supported by the results of a narrative review of the published literature. Our results show that the pattern of impairment in the COPD group is different to the pattern of impairment shown in the known Alzheimer's dementia group, with significant differences in the cognitive domains affected. These results are in keeping with the findings of other previously published studies included in the narrative review.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WF Respiratory system. Respiratory medicine
WL Nervous system. Neurology
WT Geriatrics. Elderly care
Divisions: Emergency Services > Elderly
Emergency Services > Neurology
Planned IP Care > Respiratory Medicine
Related URLs:
Depositing User: Beth Connors
Date Deposited: 21 Jun 2019 10:48
Last Modified: 21 Jun 2019 10:48
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/2162

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