Nicotinamide as Independent Variable for Intelligence, Fertility, and Health: Origin of Human Creative Explosions?

Williams, Adrian C and Hill, Lisa J (2019) Nicotinamide as Independent Variable for Intelligence, Fertility, and Health: Origin of Human Creative Explosions? International journal of tryptophan research : IJTR, 12. p. 1178646919855944. ISSN 1178-6469. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

Meat and nicotinamide acquisition was a defining force during the 2-million-year evolution of the big brains necessary for, anatomically modern, to survive. Our next move was down the food chain during the Mesolithic 'broad spectrum', then horticultural, followed by the Neolithic agricultural revolutions and progressively lower average 'doses' of nicotinamide. We speculate that a fertility crisis and population bottleneck around 40 000 years ago, at the time of the Last Glacial Maximum, was overcome by (but not the ) by concerted dietary change plus profertility genes and intense sexual selection culminating in behaviourally modern . Increased reliance on the 'de novo' synthesis of nicotinamide from tryptophan conditioned the immune system to welcome symbionts, such as TB (that excrete nicotinamide), and to increase tolerance of the foetus and thereby fertility. The trade-offs during the warmer Holocene were physical and mental stunting and more infectious diseases and population booms and busts. Higher nicotinamide exposure could be responsible for recent demographic and epidemiological transitions to lower fertility and higher longevity, but with more degenerative and auto-immune disease.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WL Nervous system. Neurology
Divisions: Emergency Services > Neurology
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Depositing User: Miss Emily Johnson
Date Deposited: 05 Jul 2019 13:36
Last Modified: 05 Jul 2019 13:36
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/2209

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