CXCL13 as biomarker for histological involvement in Sjögren's syndrome.

Colafrancesco, Serena and Priori, Roberta and Smith, Charlotte G and Minniti, Antonina and Iannizzotto, Valentina and Pipi, Elena and Lucchesi, Davide and Pontarini, Elena and Nayar, Saba and Campos, Joana and Arienzo, Francesca and Fusconi, Massimo and Cerbelli, Bruna and Giordano, Carla and Valesini, Guido and Bombardieri, Michele and Fisher, Benjamin A and Barone, Francesca (2019) CXCL13 as biomarker for histological involvement in Sjögren's syndrome. Rheumatology (Oxford, England). ISSN 1462-0332.

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Abstract

OBJECTIVES

SS is an autoimmune condition characterized by systemic B-cell activation, autoantibody production and ectopic germinal centres' formation within the salivary gland (SG). The extent of SG infiltrate has been proposed as a biomarker of disease severity. Plasma levels of CXCL13 correlate with germinal centres' activity in animal models and disease severity in SS, suggesting its potential use as a surrogate serum marker to monitor local B-cell activation. The aim of this study was to evaluate the potential role of CXCL13 as a biomarker of SG pathology in two independent SS cohorts.

METHODS

109 patients with SS were recruited at Sapienza University of Rome (Italy) (n = 60), or at Queen Elizabeth Hospital in Birmingham and Barts Health NHS Trust in London (n = 49). Both sera and matched minor SG biopsy were available. Sicca (n = 57) and healthy subjects' (n = 19) sera were used as control.

RESULTS

CXCL13 serum level was higher in SS patients compared with controls. Correlations between its serum levels and a series of histomorphological parameters, including size of the aggregates and the presence germinal centres', were observed.

CONCLUSION

Our data foster the use of CXCL13 to monitor the extent of local pathology in SS and its validation in longitudinal clinical studies.

Item Type: Article
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin > WD811 Rheumatology
Divisions: Ambulatory Care > Rheumatology
Related URLs:
Depositing User: Jennifer Manders
Date Deposited: 18 Jul 2019 14:34
Last Modified: 18 Jul 2019 14:34
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2237

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