Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis.

Coric, Danko and Ometto, Giovanni and Montesano, Giovanni and Keane, Pearse A and Balk, Lisanne J and Uitdehaag, Bernard M J and Petzold, Axel and Crabb, David P and Denniston, Alastair K (2019) Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis. European journal of neurology. ISSN 1468-1331. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/en...

Abstract

BACKGROUND

Occurrence of intermediate uveitis, which is characterized by the presence of vitreous haze (VH), in patients with multiple sclerosis (MS) may be a sign of coexistent inflammatory central nervous system (CNS) disease activity. Using an automated algorithm to quantify VH on optical coherence tomography (OCT) scans, we aimed to investigate whether VH in MS patients is associated with signs of inflammatory CNS disease activity.

METHODS

VH was quantified on OCT macular volume scans of 290 MS patients and 85 healthy controls (HCs). The relationship between VH and clinical, retinal OCT and MRI parameters of inflammatory disease activity was investigated using generalized estimating equations.

RESULTS

Mean VH scores did not differ between patients and HCs (p=0.629). Six patients (2.1%) showed values higher than the highest of the controls. VH scores did not differ between the different disease types or between eyes with and without a history of optic neuritis (p=0.132). VH was not associated with inner nuclear layer volume on OCT (p=0.233), cerebral T2 lesion load on MRI (p=0.416) or the development of new relapses (p=0.205).

CONCLUSION

In this study OCT-based automated VH estimation did not detect increased vitreous inflammation in MS patients compared to HCs, and did not find an association with CNS inflammatory burden. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WL Nervous system. Neurology
WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
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Depositing User: Mrs Yolande Brookes
Date Deposited: 26 Jul 2019 12:39
Last Modified: 26 Jul 2019 12:39
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2252

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