Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study.

Sartelli, Massimo and Abu-Zidan, Fikri M and Labricciosa, Francesco M and Kluger, Yoram and Coccolini, Federico and Ansaloni, Luca and Leppäniemi, Ari and Kirkpatrick, Andrew W and Tolonen, Matti and Tranà, Cristian and Regimbeau, Jean-Marc and Hardcastle, Timothy and Koshy, Renol M and Abbas, Ashraf and Aday, Ulaş and Adesunkanmi, A R K and Ajibade, Adesina and Akhmeteli, Lali and Akın, Emrah and Akkapulu, Nezih and Alotaibi, Alhenouf and Altintoprak, Fatih and Anyfantakis, Dimitrios and Atanasov, Boyko and Augustin, Goran and Azevedo, Constança and Bala, Miklosh and Balalis, Dimitrios and Baraket, Oussama and Baral, Suman and Barkai, Or and Beltran, Marcelo and Bini, Roberto and Bouliaris, Konstantinos and Caballero, Ana B and Calu, Valentin and Catani, Marco and Ceresoli, Marco and Charalampakis, Vasileios and Jusoh, Asri Che and Chiarugi, Massimo and Cillara, Nicola and Cuesta, Raquel Cobos and Cobuccio, Luigi and Cocorullo, Gianfranco and Colak, Elif and Conti, Luigi and Cui, Yunfeng and De Simone, Belinda and Delibegovic, Samir and Demetrashvili, Zaza and Demetriades, Demetrios and Dimova, Ana and Dogjani, Agron and Enani, Mushira and Farina, Federica and Ferrara, Francesco and Foghetti, Domitilla and Fontana, Tommaso and Fraga, Gustavo P and Gachabayov, Mahir and Gérard, Grelpois and Ghnnam, Wagih and Maurel, Teresa Giménez and Gkiokas, Georgios and Gomes, Carlos A and Guner, Ali and Gupta, Sanjay and Hecker, Andreas and Hirano, Elcio S and Hodonou, Adrien and Hutan, Martin and Ilaschuk, Igor and Ioannidis, Orestis and Isik, Arda and Ivakhov, Georgy and Jain, Sumita and Jokubauskas, Mantas and Karamarkovic, Aleksandar and Kaushik, Robin and Kenig, Jakub and Khokha, Vladimir and Khokha, Denis and Kim, Jae Il and Kong, Victor and Korkolis, Dimitris and Kruger, Vitor F and Kshirsagar, Ashok and Simões, Romeo Lages and Lanaia, Andrea and Lasithiotakis, Konstantinos and Leão, Pedro and Arellano, Miguel León and Listle, Holger and Litvin, Andrey and Lizarazu Pérez, Aintzane and Lopez-Tomassetti Fernandez, Eudaldo and Lostoridis, Eftychios and Luppi, Davide and Machain V, Gustavo M and Major, Piotr and Manatakis, Dimitrios and Reitz, Marianne Marchini and Marinis, Athanasios and Marrelli, Daniele and Martínez-Pérez, Aleix and Marwah, Sanjay and McFarlane, Michael and Mesic, Mirza and Mesina, Cristian and Michalopoulos, Nickos and Misiakos, Evangelos and Moreira, Felipe Gonçalves and Mouaqit, Ouadii and Muhtaroglu, Ali and Naidoo, Noel and Negoi, Ionut and Nikitina, Zane and Nikolopoulos, Ioannis and Nita, Gabriela-Elisa and Occhionorelli, Savino and Olaoye, Iyiade and Ordoñez, Carlos A and Ozkan, Zeynep and Pal, Ajay and Palini, Gian M and Papageorgiou, Kyriaki and Papagoras, Dimitris and Pata, Francesco and Pędziwiatr, Michał and Pereira, Jorge and Pereira Junior, Gerson A and Perrone, Gennaro and Pintar, Tadeja and Pisarska, Magdalena and Plehutsa, Oleksandr and Podda, Mauro and Poillucci, Gaetano and Quiodettis, Martha and Rahim, Tuba and Rios-Cruz, Daniel and Rodrigues, Gabriel and Rozov, Dmytry and Sakakushev, Boris and Sall, Ibrahima and Sazhin, Alexander and Semião, Miguel and Sharda, Taanya and Shelat, Vishal and Sinibaldi, Giovanni and Skicko, Dmitrijs and Skrovina, Matej and Stamatiou, Dimitrios and Stella, Marco and Strzałka, Marcin and Sydorchuk, Ruslan and Teixeira Gonsaga, Ricardo A and Tochie, Joel Noutakdie and Tomadze, Gia and Ugoletti, Lara and Ulrych, Jan and Ümarik, Toomas and Uzunoglu, Mustafa Y and Vasilescu, Alin and Vaz, Osborne and Vereczkei, Andras and Vlad, Nutu and Walędziak, Maciej and Yahya, Ali I and Yalkin, Omer and Yilmaz, Tonguç U and Ünal, Ali Ekrem and Yuan, Kuo-Ching and Zachariah, Sanoop K and Žilinskas, Justas and Zizzo, Maurizio and Pattonieri, Vittoria and Baiocchi, Gian Luca and Catena, Fausto (2019) Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study. World journal of emergency surgery : WJES, 14. p. 34. ISSN 1749-7922. This article is available to all UHB staff and students via ASK Discovery tool by using their UHB Athens login IDs

Text (PDF file format)
WJEM.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (685kB) | Preview
Official URL:



Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted.


This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018.


A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28-66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4-10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0-1, 22.7% for those who had scores of 2-3, 46.8% for those who had scores of 4-5, and 86.7% for those who have scores of 7-8.


The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool by using their UHB Athens login IDs
Subjects: WC Communicabable diseases
WI Digestive system. Gastroenterology
Divisions: Planned IP Care > General Surgery
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 26 Jul 2019 13:17
Last Modified: 26 Jul 2019 13:17

Actions (login required)

View Item View Item