Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review.

Schiffer, Lina and Barnard, Lise and Baranowski, Elizabeth S and Gilligan, Lorna C and Taylor, Angela E and Arlt, Wiebke and Shackleton, Cedric H L and Storbeck, Karl-Heinz (2019) Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review. The Journal of steroid biochemistry and molecular biology. p. 105439. ISSN 1879-1220. (In Press)

Full text not available from this repository.
Official URL: https://www.sciencedirect.com/journal/the-journal-...

Abstract

Advances in technology have allowed for the sensitive, specific, and simultaneous quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites, facilitating comprehensive characterization of the serum and urine steroid metabolomes. The quantification of steroid panels are therefore gaining favor over quantification of single marker metabolites in the clinical and research laboratories. However, although the biochemical pathways for the biosynthesis and metabolism of steroid hormones are now well defined, a gulf still exists between this knowledge and its application to the measured steroid profiles. In this review, we present an overview of steroid hormone biosynthesis and metabolism by the liver and peripheral tissues, specifically highlighting the pathways linking and differentiating the serum and urine steroid metabolomes. A brief overview of the methodology used in steroid profiling is also provided.

Item Type: Article
Subjects: WK Endocrine system. Endocrinology
Divisions: Ambulatory Care > Diabetes
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 07 Aug 2019 13:21
Last Modified: 07 Aug 2019 13:21
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2285

Actions (login required)

View Item View Item