Allergic Diseases and Long Term Risk of Autoimmune Disorders: .

Krishna, Mamidipudi Thirumala and Subramanian, Anuradhaa and Adderley, Nicola J and Zemedikun, Dawit and Gkoutos, Georgios V and Nirantharakumar, Krishnarajah (2019) Allergic Diseases and Long Term Risk of Autoimmune Disorders: . The European respiratory journal. ISSN 1399-3003.

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Official URL: https://erj.ersjournals.com/content/early/2019/08/...

Abstract

BACKGROUND

The association between allergic diseases (ADs) and autoimmune disorders (AIDs) is not well established.

OBJECTIVE

To determine incidence rates of AIDs in allergic rhinitis/conjunctivitis (ARC), atopic eczema (AE) and asthma, and investigate for co-occurring patterns.

METHODS

: Retrospective cohort study (1990-2018) employing "The Health Improvement Network" (UK primary care database).: ARC, AE and asthma - all ages.: For each exposed patient, up to 2 randomly selected age- and gender-matched controls with no documented AD.Adjusted incidence rate ratios (aIRRs) were calculated using Poisson regression. A cross-sectional study was also conducted employing Association Rule Mining (ARM) to investigate disease clusters.

RESULTS

782 320, 1 393 570 and 1 049 868 patients with ARC, AE and asthma, respectively, were included. aIRRs of systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), vitiligo, rheumatoid arthritis (RA), psoriasis, pernicious anaemia, inflammatory bowel disease (IBD), coeliac disease (CD) and autoimmune thyroid disease were uniformly higher in the 3 ADs compared to controls. Specifically, aIRRs of SLE (1.45) and SS (1.88) were higher in ARC; SLE (1.44), SS (1.61) and myasthenia (1.56) higher in asthma; SLE (1.86), SS (1.48), vitiligo (1.54) and psoriasis (2.41) higher in AE.There was no significant effect of the 3 ADs on multiple sclerosis and ARC and AE on myasthenia.ARM: ADs clustered with multiple AIDs. Three age- and gender-related clusters were identified, with relatively complex pattern in females ≥55 years.

CONCLUSION

The long-term risk of AIDs are significantly higher in patients with ADs. ADs and AIDs show age- and gender-related clustering patterns.

Item Type: Article
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin > WD300 Hypersensitivity. Allergy
WD Diseases and disorders of systemic, metabolic or environmental origin > WD350 Immunologic diseases
Divisions: Clinical Support
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Depositing User: Mrs Caroline Tranter
Date Deposited: 23 Aug 2019 11:03
Last Modified: 23 Aug 2019 11:03
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2315

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