Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.

Elhassan, Yasir S and Kluckova, Katarina and Fletcher, Rachel S and Schmidt, Mark S and Garten, Antje and Doig, Craig L and Cartwright, David M and Oakey, Lucy and Burley, Claire V and Jenkinson, Ned and Wilson, Martin and Lucas, Samuel J E and Akerman, Ildem and Seabright, Alex and Lai, Yu-Chiang and Tennant, Daniel A and Nightingale, Peter and Wallis, Gareth A and Manolopoulos, Konstantinos N and Brenner, Charles and Philp, Andrew and Lavery, Gareth G (2019) Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell reports, 28 (7). 1717-1728.e6. ISSN 2211-1247.

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Abstract

Nicotinamide adenine dinucleotide (NAD) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but human data are sparse. Nicotinamide riboside (NR) supplementation ameliorates metabolic dysfunction in rodents. We aimed to establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD metabolome and if it can alter muscle mitochondrial bioenergetics. We supplemented 12 aged men with 1 g NR per day for 21 days in a placebo-controlled, randomized, double-blind, crossover trial. Targeted metabolomics showed that NR elevated the muscle NAD metabolome, evident by increased nicotinic acid adenine dinucleotide and nicotinamide clearance products. Muscle RNA sequencing revealed NR-mediated downregulation of energy metabolism and mitochondria pathways, without altering mitochondrial bioenergetics. NR also depressed levels of circulating inflammatory cytokines. Our data establish that oral NR is available to aged human muscle and identify anti-inflammatory effects of NR.

Item Type: Article
Subjects: QU Biochemistry
Divisions: Clinical Support > Pathology
Related URLs:
Depositing User: Mrs Caroline Tranter
Date Deposited: 23 Aug 2019 13:17
Last Modified: 23 Aug 2019 13:17
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2322

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