Mesenchymal stromal cell therapy for liver diseases.

Alfaifi, Mohammed and Eom, Young Woo and Newsome, Philip N and Baik, Soon Koo (2018) Mesenchymal stromal cell therapy for liver diseases. Journal of hepatology, 68 (6). pp. 1272-1285. ISSN 1600-0641.

Full text not available from this repository.
Official URL: https://www.journal-of-hepatology.eu/article/S0168...

Abstract

The therapeutic potential of mesenchymal stromal cells (MSCs) in the treatment of liver fibrosis is predominantly based on their immunosuppressive properties, and their ability to secrete various trophic factors. This potential has been investigated in clinical and preclinical studies. Although the therapeutic mechanisms of MSC transplantation are still not fully characterised, accumulating evidence has revealed that various trophic factors secreted by MSCs play key therapeutic roles in regeneration by alleviating inflammation, apoptosis, and fibrosis as well as stimulating angiogenesis and tissue regeneration in damaged liver. In this review, we summarise the safety, efficacy, potential transplantation routes and therapeutic effects of MSCs in patients with liver fibrosis. We also discuss some of the key strategies to enhance the functionality of MSCs, which include sorting and/or priming with factors such as cytokines, as well as genetic engineering.

Item Type: Article
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin > WD350 Immunologic diseases
Divisions: Planned IP Care
Related URLs:
Depositing User: Jennifer Manders
Date Deposited: 27 Sep 2019 14:20
Last Modified: 27 Sep 2019 14:20
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2422

Actions (login required)

View Item View Item