The feasibility, safety and optimization of multiple prolonged breath-holds for radiotherapy.

Parkes, Michael John and Green, Stuart and Kilby, Warren and Cashmore, Jason and Ghafoor, Qamar and Clutton-Brock, Thomas Henry (2019) The feasibility, safety and optimization of multiple prolonged breath-holds for radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. ISSN 1879-0887. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://www.thegreenjournal.com/article/S0167-8140...

Abstract

BACKGROUND & PURPOSE

Multiple, short breath-holds are now used in single radiotherapy treatment sessions. Here we investigated the feasibility and safety of multiple prolonged breath-holds in a single session. We measured how long is a second breath-hold if we prematurely terminate a single, prolonged breath-hold of >5 min either by using a single breath of oxygen (O), or by reintroducing preoxygenation and hypocapnia. We also investigated the feasibility and safety of undertaking 9 prolonged breath-holds in a row.

MATERIALS & METHODS

30 healthy volunteers with no previous breath-holding experience were trained to perform single prolonged breath-holds safely.

RESULTS

Their mean single, prolonged breath-hold duration was 6.1 ± 0.3 se minutes (n = 30). In 18/18 subjects, premature termination (at 5.1 ± 0.2 min) with a single breath of 60% O, enabled a 2nd safe breath-hold lasting 3.3 ± 0.2 min. In 18/18 subjects, premature termination at 5.3 ± 0.2 min) by reintroducing preoxygenation and hypocapnia, enabled a 2nd safe breath-hold lasting 5.8 ± 0.3 min. 17/17 subjects could safely perform 9 successive prolonged breath-holds, each terminated (at 4.3 ± 0.2 min) by reintroducing preoxygenation and hypocapnia for 3.1 ± 0.2 min. The 9th unconstrained breath-hold (mean of 6.0 ± 0.3 min) lasted as long as their single breath-hold.

CONCLUSIONS

Multiple prolonged breath-holds are possible and safe. In a ∼19 min treatment session, it would therefore be possible to have ∼13 min for radiotherapy treatment (3 breath-holds) and ∼6 min for setup and recovery. In a 65 min session, it would be possible to have 41 min for radiotherapy and 25 min for setup and recovery.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin > WD500 Sports medicine
WN Medical imaging. Radiology
Divisions: Emergency Services > Therapies
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 02 Oct 2019 14:28
Last Modified: 02 Oct 2019 14:28
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2436

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