Multiparametric magnetic resonance imaging for quantitation of liver disease: a two-centre cross-sectional observational study.

McDonald, Natasha and Eddowes, Peter J and Hodson, James and Semple, Scott I K and Davies, Nigel P and Kelly, Catherine J and Kin, Stella and Phillips, Miranda and Herlihy, Amy H and Kendall, Timothy J and Brown, Rachel M and Neil, Desley A H and Hübscher, Stefan G and Hirschfield, Gideon M and Fallowfield, Jonathan A (2018) Multiparametric magnetic resonance imaging for quantitation of liver disease: a two-centre cross-sectional observational study. Scientific reports, 8 (1). p. 9189. ISSN 2045-2322. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://www.nature.com/articles/s41598-018-27560-5

Abstract

LiverMultiScan is an emerging diagnostic tool using multiparametric MRI to quantify liver disease. In a two-centre prospective validation study, 161 consecutive adult patients who had clinically-indicated liver biopsies underwent contemporaneous non-contrast multiparametric MRI at 3.0 tesla (proton density fat fraction (PDFF), T1 and T2* mapping), transient elastography (TE) and Enhanced Liver Fibrosis (ELF) test. Non-invasive liver tests were correlated with gold standard histothological measures. Reproducibility of LiverMultiScan was investigated in 22 healthy volunteers. Iron-corrected T1 (cT1), TE, and ELF demonstrated a positive correlation with hepatic collagen proportionate area (all p < 0·001). TE was superior to ELF and cT1 for predicting fibrosis stage. cT1 maintained good predictive accuracy for diagnosing significant fibrosis in cases with indeterminate ELF, but not for cases with indeterminate TE values. PDFF had high predictive accuracy for individual steatosis grades, with AUROCs ranging from 0.90-0.94. T2* mapping diagnosed iron accumulation with AUROC of 0.79 (95% CI: 0.67-0.92) and negative predictive value of 96%. LiverMultiScan showed excellent test/re-test reliability (coefficients of variation ranging from 1.4% to 2.8% for cT1). Overall failure rates for LiverMultiScan, ELF and TE were 4.3%, 1.9% and 15%, respectively. LiverMultiScan is an emerging point-of-care diagnostic tool that is comparable with the established non-invasive tests for assessment of liver fibrosis, whilst at the same time offering a superior technical success rate and contemporaneous measurement of liver steatosis and iron accumulation.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WI Digestive system. Gastroenterology
WN Medical imaging. Radiology
Divisions: Clinical Support > Radiology
Planned IP Care > Gastroentrology
Related URLs:
Depositing User: Beth Connors
Date Deposited: 11 Oct 2019 14:37
Last Modified: 11 Oct 2019 14:37
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2472

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