Soluble Blood Markers of Mucosal Healing in Inflammatory Bowel Disease: The Future of Noninvasive Monitoring.

Nardone, Olga Maria and Shivaji, Uday Nagesh and Ferruzza, Vittoria and Ghosh, Subrata and Iacucci, Marietta (2019) Soluble Blood Markers of Mucosal Healing in Inflammatory Bowel Disease: The Future of Noninvasive Monitoring. Inflammatory bowel diseases. ISSN 1536-4844.

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Official URL: https://academic.oup.com/ibdjournal/advance-articl...

Abstract

The traditional management of inflammatory bowel disease (IBD) based on symptom control is not considered valid anymore by most specialists in this field, and a new paradigm called "treat to target" has been introduced. This is based on the assessment of disease activity using objective measures. The identification of noninvasive biomarkers is crucial to diagnosis and monitor IBD because frequent endoscopic examinations are costly and uncomfortable for the patient. In this review, we focus on blood markers that may be able to assess mucosal healing (MH) in IBD and recent advances in this area. Introduction of commercial panel to predict MH opens the way for further developments so that colonoscopy or fecal markers may be avoided in some patients. This may also permit frequent monitoring for therapeutic response and achieve MH. It is a challenging area of research to identify a panel of biomarkers that may reflect inflammation and healing to serve as a surrogate of MH.

Item Type: Article
Subjects: WI Digestive system. Gastroenterology
Divisions: Planned IP Care > Gastroentrology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 14 Oct 2019 09:35
Last Modified: 14 Oct 2019 09:35
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2478

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