Reprint - Medical and surgical interventions for the treatment of urinary stones in children: A Cochrane Review.

Barreto, Lenka and Jung, Jae Hung and Abdelrahim, Ameera and Ahmed, Munir and Dawkins, Guy P C and Kazmierski, Marcin (2019) Reprint - Medical and surgical interventions for the treatment of urinary stones in children: A Cochrane Review. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 13 (10). pp. 334-341. ISSN 1911-6470. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://cuaj.ca/index.php/journal/article/view/578...

Abstract

INTRODUCTION

We performed systematic review to assess the effects of different medical and surgical management of urinary stones in children.

METHODS

We performed a comprehensive search using multiple databases (MEDLINE, EMBASE, Cochrane Register of Controlled Trials), trials registries (World Health Organization International Clinical Trials Registry Platform Search Portal and ClinicalTrials.gov), and abstract proceedings of major urological and pediatric urology meetings, with no restrictions on the language of publication or publication status, up until December 2017. We included all randomized controlled trials (RCTs) and quasi-RCTs. Two review authors independently assessed the eligibility of studies for inclusion, extracted data, and assessed risk of bias in accordance with the Cochrane "Risk of bias" tool. We performed statistical analyses using a random-effects model and assessed the quality of the evidence according to GRADE.

RESULTS

We included 14 studies with a total of 978 randomized participants in our review, informing seven comparisons with shock wave lithotripsy, percutaneous nephrolithotripsy, ureterorenoscopy (regardless of the type of lithotripsy), open stone surgery, and medical expulsive therapy. There was very low quality of evidence in the most comparisons with regards to the effectiveness and adverse events for the treatment of pediatric upper renal tract stone disease.

CONCLUSIONS

Based on mostly very low-quality evidence for most comparisons and outcomes, we are uncertain about the effect of nearly all medical and surgical interventions to treat stone disease in children. There is a critical need for better-quality trials assessing patient-important outcomes in children with stone disease to inform future guidelines on the management of this condition.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WJ Urogenital system. Urology
Divisions: Planned IP Care > Urology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 21 Oct 2019 10:59
Last Modified: 21 Oct 2019 10:59
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2506

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