Evidence for Arrhythmogenic Effects of A-Adenosine Receptors.

Boknik, Peter and Drzewiecki, Katharina and Eskandar, John and Gergs, Ulrich and Hofmann, Britt and Treede, Hendrik and Grote-Wessels, Stephanie and Fabritz, Larissa and Kirchhof, Paulus and Fortmüller, Lisa and Müller, Frank Ulrich and Schmitz, Wilhelm and Zimmermann, Norbert and Kirchhefer, Uwe and Neumann, Joachim (2019) Evidence for Arrhythmogenic Effects of A-Adenosine Receptors. Frontiers in pharmacology, 10. p. 1051. ISSN 1663-9812.

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Official URL: https://www.frontiersin.org/articles/10.3389/fphar...

Abstract

Adenosine can be released from the heart and may stimulate four different cardiac adenosine receptors. A receptor subtype that couples to the generation of cyclic adenosine monophosphate (cAMP) is the A-adenosine receptor (A-AR). To better understand its role in cardiac function, we studied mechanical and electrophysiological effects in transgenic mice that overexpress the human A-AR in cardiomyocytes (A-TG). We used isolated preparations from the left atrium, the right atrium, isolated perfused hearts with surface electrocardiogram (ECG) recording, and surface body ECG recordings of living mice. The hypothesized arrhythmogenic effects of transgenicity per se and A-AR stimulation were studied. We noted an increase in the incidence of supraventricular and ventricular arrhythmias under these conditions in A-TG. Moreover, we noted that the A-AR agonist CGS 21680 exerted positive inotropic effect in isolated human electrically driven (1 Hz) right atrial trabeculae carneae. We conclude that A-ARs are functional not only in A-TG but also in isolated human atrial preparations. A-ARs in A-TG per se and their stimulation can lead to cardiac arrhythmias not only in isolated cardiac preparations from A-TG but also in living A-TG.

Item Type: Article
Subjects: WG Cardiovascular system. Cardiology
Divisions: Emergency Services > Cardiology
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Depositing User: Mrs Yolande Brookes
Date Deposited: 23 Oct 2019 13:40
Last Modified: 23 Oct 2019 13:40
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2514

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