Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy.

Rajabally, Yusuf A and Ghasemi, Majid (2019) Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy. Muscle & nerve. ISSN 1097-4598. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

Full text not available from this repository.
Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/mu...

Abstract

INTRODUCTION

The comparative value and suitability of outcome measures are uncertain in chronic inflammatory demyelinating polyneuropathy (CIDP).

METHODS

We studied 35 patients with CIDP using the Overall Neuropathy Limitation Scale (ONLS), the inflammatory Rasch-built Overall Disability Scale (I-RODS) and the Medical Research Council Sum Score (MRCSS).

RESULTS

Significant associations were determined between initial deficit and ONLS (p=0.002) and MRCSS improvement (p=0.001), but not I-RODS. A strong inverse correlation was observed between disease duration and I-RODS (p=0.002), but not ONLS/MRCSS improvement. A strong association was observed between age ≤40 years and I-RODS (p=0.001), but not ONLS/MRCSS improvement. Using minimum important differences, ONLS and I-RODS sensitivities were comparable (p=0.19).

DISCUSSION

ONLS and I-RODS are equally sensitive in identifying change. Ease of administration, better ability to detect improvement in severe disease, greater amplitude responses throughout the disease and in older subjects, favor the ONLS. The I-RODS appears more useful in early disease/younger patients. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WE Musculoskeletal. Orthopaedics
Divisions: Ambulatory Care > Rheumatology
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 01 Nov 2019 12:00
Last Modified: 01 Nov 2019 12:00
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2541

Actions (login required)

View Item View Item