Humoral immunity in late-onset Pre-eclampsia and linkage with angiogenic and inflammatory markers.

Sarween, Nadia and Drayson, Mark T and Hodson, James and Knox, Ellen M and Plant, Timothy and Day, Clara J and Lipkin, Graham W (2018) Humoral immunity in late-onset Pre-eclampsia and linkage with angiogenic and inflammatory markers. American journal of reproductive immunology (New York, N.Y. : 1989), 80 (5). e13041. ISSN 1600-0897. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/aj...

Abstract

PROBLEM

Pre-eclampsia (PE) is a leading cause of maternal and foetal morbidity worldwide. Given the implication of immune mechanisms, we compared markers of humoral immunity in PE and their relationship to circulating markers of inflammation, angiogenic factors, and renal function.

METHOD OF STUDY

Serum samples from 88 previously healthy women admitted to hospital with PE and 107 healthy pregnant controls at term were analysed for serum immunoglobulins (Ig), including IgG subclasses and free light chain (sFLC) levels, beta-2 microglobulin (B2-M), high-sensitivity C-reactive protein (HS-CRP), albumin, complement proteins (C3 & C4), creatinine, cystatin-C and the ratio of soluble fms-like tyrosine kinase-1 (sFLT-1) and placental growth factor (PlGF).

RESULTS

Compared to the controls, women with PE had significantly reduced renal function, serum IgG (subclass 1 & 3), albumin, and C4 levels, whilst concentrations of total sFLC, HS-CRP, B2-M, and sFLT-1:PlGF were raised. On multivariable analysis, sFLT-1:PlGF ratio (P < 0.001), sFLC (P < 0.001) and IgG1 (P < 0.024) were found to be independently associated with PE, after accounting for renal function, patient age, BMI, ethnicity, and parity. B2-M and sFLT-1:PlGF had comparable diagnostic association with PE (P = 0.184), and correlated strongly with each other (ρ = 0.588, P < 0.001) as well as with renal function and adverse clinical outcome.

CONCLUSION

We describe for the first time that PE is independently associated with activation of the humoral immune system independent of deranged kidney function and angiogenic markers. The role of B2-M as a potential predictive marker of PE remains to be determined.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QW Microbiology. Immunology
WJ Urogenital system. Urology
WQ Obstetrics. Midwifery
Divisions: Emergency Services > Renal
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Depositing User: Beth Connors
Date Deposited: 06 Nov 2019 16:49
Last Modified: 06 Nov 2019 16:49
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2555

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