Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4 T Cell Engulfment Process.

Davies, Scott P and Reynolds, Gary M and Wilkinson, Alex L and Li, Xiaoyan and Rose, Rebecca and Leekha, Maanav and Liu, Yuxin S and Gandhi, Ratnam and Buckroyd, Emma and Grove, Joe and Barnes, Nicholas M and May, Robin C and Hubscher, Stefan G and Adams, David H and Huang, Yuehua and Qureshi, Omar and Stamataki, Zania (2019) Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4 T Cell Engulfment Process. Cell reports, 29 (6). 1610-1620.e4. ISSN 2211-1247.

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CD4 T cells play critical roles in directing immunity, both as T helper and as regulatory T (Treg) cells. Here, we demonstrate that hepatocytes can modulate T cell populations through engulfment of live CD4 lymphocytes. We term this phenomenon enclysis to reflect the specific enclosure of CD4 T cells in hepatocytes. Enclysis is selective for CD4 but not CD8 cells, independent of antigen-specific activation, and occurs in human hepatocytes in vitro, ex vivo, and in vivo. Intercellular adhesion molecule 1 (ICAM-1) facilitates T cell early adhesion and internalization, whereas hepatocytes form membrane lamellipodia or blebs to mediate engulfment. T cell internalization is unaffected by wortmannin and Rho kinase inhibition. Hepatocytes engulf Treg cells more efficiently than non-Treg cells, but Treg cell-containing vesicles preferentially acidify overnight. Thus, enclysis is a biological process with potential effects on immunomodulation and opens a new field for research to fully understand CD4 T cell dynamics in liver inflammation.

Item Type: Article
Subjects: WI Digestive system. Gastroenterology
Divisions: Clinical Support > Pathology
Emergency Services > Renal
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Depositing User: Mrs Yolande Brookes
Date Deposited: 08 Nov 2019 13:43
Last Modified: 08 Nov 2019 13:43
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2561

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