Machine perfusion strategies in liver transplantation.

Schlegel, Andrea and Muller, Xavier and Dutkowski, Philipp (2019) Machine perfusion strategies in liver transplantation. Hepatobiliary surgery and nutrition, 8 (5). pp. 490-501. ISSN 2304-3881. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://hbsn.amegroups.com/article/view/26099/25693

Abstract

Machine perfusion is a hot topic in liver transplantation and several new perfusion concepts are currently developed. Prior to introduction into routine clinical practice, however, such perfusion approaches need to demonstrate their impact on liver function, post-transplant complications, utilization rates of high-risk organs, and cost benefits. Therefore, based on results of experimental and clinical studies, the community has to recognize the limitations of this technology. In this review, we summarize current perfusion concepts and differences between protective mechanisms of and perfusion techniques. Next, we discuss which graft types may benefit most from perfusion techniques, and highlight the current understanding of liver viability testing. Finally, we present results from recent clinical trials involving machine liver perfusion, and analyze the value of different outcome parameters, currently used as endpoints for randomized controlled trials in the field.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WI Digestive system. Gastroenterology
WJ Urogenital system. Urology
Divisions: Planned IP Care > Gastroentrology
Planned IP Care > Urology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 08 Nov 2019 14:42
Last Modified: 08 Nov 2019 14:42
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2570

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