HEART UK consensus statement on Lipoprotein(a): A call to action.

Cegla, Jaimini and Neely, R Dermot G and France, Michael and Ferns, Gordon and Byrne, Chris D and Halcox, Julian and Datta, Dev and Capps, Nigel and Shoulders, Carol and Qureshi, Nadeem and Rees, Alan and Main, Linda and Cramb, Robert and Viljoen, Adie and Payne, Jules and Soran, Handrean (2019) HEART UK consensus statement on Lipoprotein(a): A call to action. Atherosclerosis, 291. pp. 62-70. ISSN 1879-1484.

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Official URL: https://www.atherosclerosis-journal.com/article/S0...

Abstract

Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a) is an independent cardiovascular disease (CVD) risk factor, provides recommendations for its measurement in clinical practice and reviews current and emerging therapeutic strategies to reduce CVD risk. Ten statements summarise the most salient points for practitioners and patients with high Lp(a). HEART UK recommends that Lp(a) is measured in adults as follows: 1) those with a personal or family history of premature atherosclerotic CVD; 2) those with first-degree relatives who have Lp(a) levels >200 nmol/l; 3) patients with familial hypercholesterolemia; 4) patients with calcific aortic valve stenosis and 5) those with borderline (but <15%) 10-year risk of a cardiovascular event. The management of patients with raised Lp(a) levels should include: 1) reducing overall atherosclerotic risk; 2) controlling dyslipidemia with a desirable non-HDL-cholesterol level of <100 mg/dl (2.5 mmol/l) and 3) consideration of lipoprotein apheresis.

Item Type: Article
Subjects: QU Biochemistry
WB Practice of medicine
WG Cardiovascular system. Cardiology
Divisions: Emergency Services > Cardiology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 15 Nov 2019 13:23
Last Modified: 15 Nov 2019 13:23
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2593

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