Instrument-based tests for quantifying aqueous humour protein levels in uveitis: a systematic review protocol.

McNally, Thomas W and Liu, Xiaoxuan and Beese, Sophie and Keane, Pearse A and Moore, David J and Denniston, Alastair K (2019) Instrument-based tests for quantifying aqueous humour protein levels in uveitis: a systematic review protocol. Systematic reviews, 8 (1). p. 287. ISSN 2046-4053. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

[img]
Preview
Text (PDF file format)
systematic reviews.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (564kB) | Preview
Official URL: https://systematicreviewsjournal.biomedcentral.com...

Abstract

BACKGROUND

Inflammation in anterior uveitis is characterised by breakdown of the blood-ocular barrier, which allows leakage of blood constituents of higher molecular weight into the aqueous humour. In routine clinical care, increase in aqueous protein levels can be observed at the slit lamp as 'flare' and the severity can be graded using various clinical grading systems, of which the Standardization of Uveitis Nomenclature (SUN) grading system is most commonly used. Alternative instrument-based technologies are available, which can detect aqueous protein levels in an objective and quantifiable way. This review will identify instruments capable of measuring anterior chamber inflammation in this way, their level of reliability, and how well the measurements correlate with clinical grading and/or actual aqueous protein concentration.

METHODS

Standard systematic review methodology will be used to identify, select and extract data from studies that report the use of any instrument-based technology in the assessment of aqueous protein levels. Searches will be conducted through bibliographic databases (MEDLINE, EMBASE and Cochrane Library), clinical trial registries and the grey literature. No restrictions will be placed on language or year of publication. The outcomes of interest are the level of correlation between identified instrument-based test measurements, clinical grading and/or actual aqueous protein concentration, as well as the reliability of each index test identified. Study quality assessment will be based on QUADAS2. Correlation and reliability outcomes will be pooled and meta-analysed if appropriate.

DISCUSSION

The assessment of inflammation in anterior chamber protein levels currently relies on crude and subjective clinical examination. The findings of this review will identify non-invasive technologies which show good correlation with actual protein concentration, which could be used in routine clinical practice for objective monitoring of AC inflammation.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO CRD42017084167. Study screening stage has just been completed.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 29 Nov 2019 15:52
Last Modified: 29 Nov 2019 15:52
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2653

Actions (login required)

View Item View Item