The Effectiveness of Pharmacological Agents for the Treatment of Uveitic Macular Edema (UMO): A Systematic Review.

Tallouzi, Mohammad O and Moore, David J and Barry, Robert J and Calvert, Melanie and Mathers, Jonathan and Murray, Philip I and Denniston, Alastair K (2019) The Effectiveness of Pharmacological Agents for the Treatment of Uveitic Macular Edema (UMO): A Systematic Review. Ocular immunology and inflammation, 27 (4). pp. 658-680. ISSN 1744-5078.

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Official URL: https://www.tandfonline.com/doi/abs/10.1080/092739...

Abstract

: To conduct a systematic review of effectiveness of pharmacological therapies for treatment of Uveitic Macular Edema (UMO). : Comparative studies of pharmacological therapies in patients with UMO were identified in Cochrane CENTRAL/MEDLINE/EMBASE/CINAHL/trials registers (February 2017). PROSPERO registration: CRD42015019170. : Thirty-one studies were included. Corticosteroids were the most frequently studied ( = 20). Corticosteroids (all forms) were consistently of greater/equal efficacy to active comparators; for anti-VEGF ( = 4) improvement, best-corrected visual acuity (BCVA) and central macular thickness (CMT) were mostly less than local corticosteroid injection; for interferon ( = 1) improvement BCVA and CMT were greater than the comparator of methotrexate; for topical indomethacin ( = 1) improvement, BCVA and CMT were greater than placebo. Non-steroidal anti-inflammatory drugs, carbonic anhydrase inhibitors, and vitamin E ( = 5) were not effective for these outcomes. : The review highlights areas where the evidence base is still lacking, and appropriately focused trials are needed to inform best treatment to tackle this sight-threatening condition.

Item Type: Article
Subjects: WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
Related URLs:
Depositing User: Beth Connors
Date Deposited: 03 Jan 2020 16:04
Last Modified: 03 Jan 2020 16:04
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2740

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