Case of small bowel perforation secondary to nivolumab and ipilimumab related tumour regression.

Patel, Kishen Rajan and Lee, Lennard Yw and Tripathy, Arvind and McKean, David (2020) Case of small bowel perforation secondary to nivolumab and ipilimumab related tumour regression. BMJ case reports, 13 (2). ISSN 1757-790X. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://casereports.bmj.com/content/13/2/e232304.l...

Abstract

A 56-year-old man undergoing immunotherapy treatment for metastatic melanoma presented with sudden onset testicular pain radiating into his abdomen. On examination, the abdomen was generally tender with associated guarding. Imaging revealed a perforation of the small bowel at the site of a metastatic lesion. Histology revealed that this process was non-inflammatory in nature. A diagnosis of small bowel perforation secondary to immunotherapy driven rapid tumour regression was made. The patient was treated with a small bowel resection plus anastomosis and made a full recovery. This case highlights the rare potential side effect of immunotherapy in causing non-inflammatory bowel perforations secondary to rapid tumour regression.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QZ Pathology. Oncology
Divisions: Planned IP Care > Oncology and Clinical Haematology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 03 Mar 2020 14:27
Last Modified: 03 Mar 2020 14:27
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2894

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