Utility of volatile organic compounds as a diagnostic tool in preterm infants.

Wright, Harriet and Bannaga, Ayman S and Iriarte, Rolland and Mahmoud, Mshail and Arasaradnam, Ramesh P (2020) Utility of volatile organic compounds as a diagnostic tool in preterm infants. Pediatric research. ISSN 1530-0447. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://www.nature.com/articles/s41390-020-0828-3

Abstract

BACKGROUND

Volatile organic compounds (VOCs) are hydrocarbons that originate within different healthy and diseased tissues. VOCs can be secreted into the circulation and then excreted in the urine and faeces. In the lungs, VOCs are locally produced and can be detected in exhaled breath. VOCs can be identified using non-invasive techniques, which make their use in preterm infants safe and desirable.

METHODS

A systematic search of the literature in PubMed, Embase and Web of Science was conducted looking for VOCs techniques and diagnostic performance in preterm infants. A total of 50 articles identified with only seven papers were included in the final analysis in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

RESULTS

VOCs could diagnose necrotising enterocolitis up to 4 days before a clinical diagnosis; for late onset sepsis, up to 3 days before; and for bronchopulmonary dysplasia, up to 2 weeks before. In addition to these diagnostic uses, VOCs analysis could also distinguish breastfed from formula-fed preterm neonates in the first month of life.

CONCLUSION

VOCs analysis is a non-invasive tool that makes the use in preterm infants of preference. VOCs analytic techniques require more research and consensus between researchers to overcome their limitations.

IMPACT

Volatile organic compounds are hydrocarbons that can separate between healthy and diseased states in preterm infants.Biomarker panels developed from volatile organic compounds are potential diagnostic tools.The non-invasive nature of acquiring volatile organic compounds markers make it desirable in the paediatric patients.Research into exact chemical components of the volatile organic compounds can inform about the pathophysiology of disease in preterm infants.More robust longitudinal studies with repeated experiments are required before volatile organic compounds can be applied in clinical practice.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WS Paediatrics. Child health
Divisions: Womens and Childrens > Paediatrics
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 06 Mar 2020 15:07
Last Modified: 06 Mar 2020 15:07
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2917

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