Biomarkers of Liver Injury during Transplantation in an Era of Machine Perfusion.

Bhogal, Ricky H and Mirza, Darius F and Afford, Simon C and Mergental, Hynek (2020) Biomarkers of Liver Injury during Transplantation in an Era of Machine Perfusion. International journal of molecular sciences, 21 (5). ISSN 1422-0067. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

Liver ischaemia-reperfusion injury (IRI) is an intrinsic part of the transplantation process and damages the parenchymal cells of the liver including hepatocytes, endothelial cells and cholangiocytes. Many biomarkers of IRI have been described over the past two decades that have attempted to quantify the extent of IRI involving different hepatic cellular compartments, with the aim to allow clinicians to predict the suitability of donor livers for transplantation. The advent of machine perfusion has added an additional layer of complexity to this field and has forced researchers to re-evaluate the utility of IRI biomarkers in different machine preservation techniques. In this review, we summarise the current understanding of liver IRI biomarkers and discuss them in the context of machine perfusion.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QW Microbiology. Immunology
WI Digestive system. Gastroenterology
WO Surgery
Divisions: Planned IP Care > Gastroentrology
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Depositing User: Jamie Edgar
Date Deposited: 06 Mar 2020 15:30
Last Modified: 06 Mar 2020 15:30
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2918

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