Typical and atypical carcinoid tumors of the lung: A Clinicopathological correlation OF OF 783 cases with Emphasis on histological features.

Moran, Cesar A and Lindholm, Kaleigh E and Brunnström, Hans and Langman, Gerald and Jang, Se Jin and Spagnolo, Dominic and Chai, Siaw Ming and Laycock, Andrew and Falconieri, Giovanni and Pizzolitto, Stefano and de Pellegrin, Alessandro and Medeiros, Filomena and Edmunds, Lilian and Catarino, Ana and Cunha, Fernando and Ro, Jae and Pina-Oviedo, Sergio and Torrealba, Jose and Coppola, Domenico and Petersson, Fredrik and Oon, Ming Lian and Elmberger, Goran and Cajal, Santiago Ramon Y and Valero, Irene Sansano and Dalurzo, Liliana and Soares, Fernando and Campos, Antonio H and Vranic, Semir and Skenderi, Faruk and Correa, Arlene M and Sepesi, Boris and Rice, David and Mehran, Reza and Walsh, Garrett (2020) Typical and atypical carcinoid tumors of the lung: A Clinicopathological correlation OF OF 783 cases with Emphasis on histological features. Human pathology. ISSN 1532-8392. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcome. Long-term follow-up was obtained in all the patients and statistically analyzed to determine significance of the different parameters evaluated. Of the histopathological features analyzed, the presence of mitotic activity of 4 mitoses or more per 2mm, necrosis, lymphatic invasion and lymph node metastasis were identified as statistically significant. Tumors measuring 3 cm or more were also identified as statistically significant and correlate with clinical outcome. Based on our analysis, we consider that the separation of low and intermediate grade neuroendocrine neoplasms of the lung needs to be readjusted in terms of mitotic count as the risk of over grading these neoplasms exceeds 10% under the current criteria. We also consider that tumor size is an important feature to be considered in the assessment of these neoplasms and together with the histological grade of the tumor offers important features that can be correlated with clinical outcome.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QZ Pathology. Oncology
Divisions: Planned IP Care > Oncology and Clinical Haematology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 13 Mar 2020 14:48
Last Modified: 13 Mar 2020 14:48
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2929

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