Pituitary metastases: presentation and outcomes from a pituitary center over the last decade.

Lithgow, Kirstie and Siqueira, I and Senthil, L and Chew, H S and Chavda, S V and Ayuk, John and Toogood, Andrew and Gittoes, Neil and Matthews, Tim and Batra, R and Meade, S and Sanghera, Paul and Khan, N and Ahmed, Shahzada and Paluzzi, A and Tsermoulas, G and Karavitaki, Niki (2020) Pituitary metastases: presentation and outcomes from a pituitary center over the last decade. Pituitary. ISSN 1573-7403.

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Official URL: https://link.springer.com/article/10.1007%2Fs11102...

Abstract

PURPOSE

Highlight and characterize manifestations, diagnostic/management approaches and outcomes in a contemporary cohort of patients with pituitary metastases (PM) from a large European pituitary center-over 10 years.

METHODS

Retrospective review of PM cases between 1/2009 and 12/2018. Clinical, laboratory, imaging data at PM detection and during follow-up were analysed.

RESULTS

18 cases were identified (14 females; median age at diagnosis 61.5 years). Most common primary malignancies were lung (39%) and breast (32%). Most frequent presenting manifestation was visual dysfunction (50%). Gonadotrophin, ACTH, TSH deficiency were diagnosed in 85%, 67%, 46% of cases, respectively; diabetes insipidus (DI) was present in 17%. 33% of cases were detected during investigation for symptoms unrelated to PM. PM management included radiotherapy (44%), transsphenoidal surgery (17%), transsphenoidal surgery and radiotherapy (6%) or monitoring only (33%). One-year survival was 49% with median survival from PM detection 11 months (range 2-47).

CONCLUSIONS

In our contemporary series, clinical presentation of PM has evolved; we found increased prevalence of anterior hypopituitarism, decreased rates of DI and longer survival compared with older literature. Increased availability of diagnostic imaging, improvements in screening and recognition of pituitary disease and longer survival of patients with metastatic cancer may be contributing factors.

Item Type: Article
Subjects: WK Endocrine system. Endocrinology
Divisions: Ambulatory Care > Endocrinology
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Depositing User: Mrs Caroline Tranter
Date Deposited: 23 Mar 2020 10:26
Last Modified: 23 Mar 2020 10:26
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2942

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