Metabolic Concepts in Idiopathic Intracranial Hypertension and Their Potential for Therapeutic Intervention.

Hornby, Catherine and Mollan, Susan P and Botfield, Hannah and OʼReilly, Michael W and Sinclair, Alexandra J (2018) Metabolic Concepts in Idiopathic Intracranial Hypertension and Their Potential for Therapeutic Intervention. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 38 (4). pp. 522-530. ISSN 1536-5166.

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Official URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC62154...

Abstract

BACKGROUND

Traditional risk factors associated with idiopathic intracranial hypertension (IIH) include obesity, weight gain, and female sex. The incidence of IIH is increasing and yet the underlying trigger and the fueling pathological mechanisms are still poorly understood.

EVIDENCE ACQUISITION

Review of ophthalmology, neurology, general surgery, obesity, endocrinology, nutrition, and neurosurgery literature was made.

RESULTS

The facts that implicate sex and obesity in IIH and headache are examined. The role of fat distribution in IIH is questioned, and the concept of adipose tissue functioning as an endocrine organ driving IIH is discussed. The impact of androgen metabolism in IIH is reviewed as is the emerging role of glucagon-like-peptide-1 analogues in modulating intracranial pressure. This introduces the concept of developing targeted disease-modifying therapeutic strategies for IIH.

CONCLUSIONS

This review will discuss the possible role of the adipose/gut/brain metabolism axis in IIH and speculate how this may impact the pathogenesis of IIH and therapeutic opportunities.

Item Type: Article
Subjects: WL Nervous system. Neurology
WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
Emergency Services > Neurology
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Depositing User: Mr Muneeb Liaquat
Date Deposited: 01 Apr 2020 11:57
Last Modified: 01 Apr 2020 11:57
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2948

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