Antioxidant Therapies in Traumatic Brain Injury.

Di Pietro, Valentina and Yakoub, Kamal M and Caruso, Giuseppe and Lazzarino, Giacomo and Signoretti, Stefano and Barbey, Aron K and Tavazzi, Barbara and Lazzarino, Giuseppe and Belli, Antonio and Amorini, Angela Maria (2020) Antioxidant Therapies in Traumatic Brain Injury. Antioxidants (Basel, Switzerland), 9 (3). ISSN 2076-3921. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://www.mdpi.com/2076-3921/9/3/260

Abstract

Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly heterogeneous pathology, characterized by high mortality and disability rates. TBI is an acute neurodegenerative event, potentially and unpredictably evolving into sub-chronic and chronic neurodegenerative events, with transient or permanent neurologic, cognitive, and motor deficits, for which no valid standardized therapies are available. A vast body of literature demonstrates that TBI-induced oxidative/nitrosative stress is involved in the development of both acute and chronic neurodegenerative disorders. Cellular defenses against this phenomenon are largely dependent on low molecular weight antioxidants, most of which are consumed with diet or as nutraceutical supplements. A large number of studies have evaluated the efficacy of antioxidant administration to decrease TBI-associated damage in various animal TBI models and in a limited number of clinical trials. Points of weakness of preclinical studies are represented by the large variability in the TBI model adopted, in the antioxidant tested, in the timing, dosages, and routes of administration used, and in the variety of molecular and/or neurocognitive parameters evaluated. The analysis of the very few clinical studies does not allow strong conclusions to be drawn on the real effectiveness of antioxidant administration to TBI patients. Standardizing TBI models and different experimental conditions, as well as testing the efficacy of administration of a cocktail of antioxidants rather than only one, should be mandatory. According to some promising clinical results, it appears that sports-related concussion is probably the best type of TBI to test the benefits of antioxidant administration.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin
WL Nervous system. Neurology
Divisions: Clinical Support > Critical Care
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Depositing User: Mrs Yolande Brookes
Date Deposited: 08 Apr 2020 13:43
Last Modified: 08 Apr 2020 13:43
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2973

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