Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck.

Golusinski, Pawel and Di Maio, Pasquale and Pehlivan, Berrin and Colley, Steve and Nankivell, Paul and Kong, Anthony and Hartley, Andrew and Mehanna, Hisham (2019) Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck. Oral oncology, 88. pp. 145-152. ISSN 1879-0593. This article is available to all UHB staff and students via ASK Discovery Tool http://tinyurl.com/z795c8cby using their UHB Athens login IDs

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Abstract

Metastases to the cervical lymph nodes from a occult primary (CUP) of head and neck squamous carcinomas has been increasing in presentation (HNSCC). Modern diagnostic workup, including clinical evaluation, conventional imaging, FDG-PET/CT and panendoscopy/tonsillectomy enables detection of the primary site in over half of all cases, and is associated with significantly improved survival rates. Recent studies have demonstrated the utility of novel molecular pathology and transoral surgical techniques in improving diagnosis and treatment. We present a new, evidence-based protocol incorporating these novel diagnostic modalities. It aims to identify the site of the primary tumor, and determine the stage of the disease, including extranodal extension. This information can personalise treatment recommendations, rationalise combinations of treatment modalities, and thereby potentially minimise toxicity and improving functional outcomes.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery Tool http://tinyurl.com/z795c8cby using their UHB Athens login IDs
Subjects: WU Dentistry. Oral surgery
Divisions: Planned IP Care > Oncology and Clinical Haematology
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Depositing User: Stephen Yates
Date Deposited: 21 Apr 2020 11:38
Last Modified: 10 Jul 2020 13:17
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2992

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