Performance validation of the ALPPS risk model.

Linecker, Michael and Kuemmerli, Christoph and Kambakamba, Patryk and Schlegel, Andrea and Muiesan, Paolo and Capobianco, Ivan and Nadalin, Silvio and Torres, Orlando J and Mehrabi, Arianeb and Stavrou, Gregor A and Oldhafer, Karl J and Lurje, Georg and Balci, Deniz and Lang, Hauke and Robles-Campos, Ricardo and Hernandez-Alejandro, Roberto and Malago, Massimo and De Santibanes, Eduardo and Clavien, Pierre-Alain and Petrowsky, Henrik (2019) Performance validation of the ALPPS risk model. HPB : the official journal of the International Hepato Pancreato Biliary Association, 21 (6). pp. 711-721. ISSN 1477-2574.

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Abstract

BACKGROUND

Based on the International ALPPS registry, we have recently proposed two easily applicable risk models (pre-stage1 and 2) for predicting 90-day mortality in ALPPS but a validation of both models has not been performed yet.

METHODS

The validation cohort (VC) was composed of subsequent cases of the ALPPS registry and cases of centers outside the ALPPS registry.

RESULTS

The VC was composed of a total of 258 patients including 70 patients outside the ALPPS registry with 32 cases of early mortalities (12%). Development cohort (DC) and VC were comparable in terms of patient and surgery characteristics. The VC validated both models with an acceptable prediction for the pre-stage 1 (c-statistic 0.64, P = 0.009 vs. 0.77, P < 0.001) and a good prediction for the pre-stage 2 model (c-statistic 0.77, P < 0.001 vs. 0.85, P < 0.001) as compared to the DC. Overall model performance measured by Brier score was comparable between VC and DC for the pre-stage 1 (0.089 vs. 0.081) and pre-stage 2 model (0.079 vs. 0087).

CONCLUSION

The ALPPS risk score is a fully validated model to estimate the individual risk of patients undergoing ALPPS and to assist clinical decision making to avoid procedure-related early mortality after ALPPS.

Item Type: Article
Subjects: WI Digestive system. Gastroenterology
WO Surgery
Related URLs:
Depositing User: Stephen Yates
Date Deposited: 21 Apr 2020 15:00
Last Modified: 10 Jul 2020 13:24
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3004

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