Transplantation of discarded livers following viability testing with normothermic machine perfusion.

Mergental, Hynek and Laing, Richard W and Kirkham, Amanda J and Perera, M Thamara P R and Boteon, Yuri L and Attard, Joseph and Barton, Darren and Curbishley, Stuart and Wilkhu, Manpreet and Neil, Desley A H and Hübscher, Stefan G and Muiesan, Paolo and Isaac, John R and Roberts, Keith J and Abradelo, Manuel and Schlegel, Andrea and Ferguson, James and Cilliers, Hentie and Bion, Julian and Adams, David H and Morris, Chris and Friend, Peter J and Yap, Christina and Afford, Simon C and Mirza, Darius F (2020) Transplantation of discarded livers following viability testing with normothermic machine perfusion. Nature communications, 11 (1). p. 2939. ISSN 2041-1723.

Text (PDF file format)
Nature.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (1MB) | Preview
Official URL:


There is a limited access to liver transplantation, however, many organs are discarded based on subjective assessment only. Here we report the VITTAL clinical trial ( number NCT02740608) outcomes, using normothermic machine perfusion (NMP) to objectively assess livers discarded by all UK centres meeting specific high-risk criteria. Thirty-one livers were enroled and assessed by viability criteria based on the lactate clearance to levels ≤2.5 mmol/L within 4 h. The viability was achieved by 22 (71%) organs, that were transplanted after a median preservation time of 18 h, with 100% 90-day survival. During the median follow up of 542 days, 4 (18%) patients developed biliary strictures requiring re-transplantation. This trial demonstrates that viability testing with NMP is feasible and in this study enabled successful transplantation of 71% of discarded livers, with 100% 90-day patient and graft survival; it does not seem to prevent non-anastomotic biliary strictures in livers donated after circulatory death with prolonged warm ischaemia.

Item Type: Article
Subjects: WI Digestive system. Gastroenterology
WO Surgery
Divisions: Clinical Support > Anaesthetics
Clinical Support > Pathology
Planned IP Care > Gastroentrology
Planned IP Care > General Surgery
Clinical Support > Immunology
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 25 Jun 2020 11:39
Last Modified: 25 Jun 2020 11:39

Actions (login required)

View Item View Item