A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

Speedy, Helen E and Di Bernardo, Maria Chiara and Sava, Georgina P and Dyer, Martin J S and Holroyd, Amy and Wang, Yufei and Sunter, Nicola J and Mansouri, Larry and Juliusson, Gunnar and Smedby, Karin E and Roos, Göran and Jayne, Sandrine and Majid, Aneela and Dearden, Claire and Hall, Andrew G and Mainou-Fowler, Tryfonia and Jackson, Graham H and Summerfield, Geoffrey and Harris, Robert J and Pettitt, Andrew R and Allsup, David J and Bailey, James R and Pratt, Guy and Pepper, Chris and Fegan, Chris and Rosenquist, Richard and Catovsky, Daniel and Allan, James M and Houlston, Richard S (2014) A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Nature genetics, 46 (1). pp. 56-60. ISSN 1546-1718.

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Official URL: http://www.nature.com/ng/journal/v46/n1/full/ng.28...


Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.

Item Type: Article
Subjects: QZ Pathology. Oncology
WH Haemic and lymphatic systems. Haematology
Divisions: Planned IP Care > Oncology and Clinical Haematology
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Depositing User: Sophie Rollason
Date Deposited: 09 Jul 2014 08:32
Last Modified: 09 Jul 2014 08:32
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/588

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