Tools
Tools
Wong, Gabriel K and Huissoon, Aarnoud P (2016) T-cell abnormalities in common variable immunodeficiency: the hidden defect. Journal of clinical pathology, 69 (8). pp. 672-6. ISSN 1472-4146.
Full text not available from this repository.Abstract
This review discusses how the T-cell compartment in common variable immunodeficiency is marked by the premature arrest in thymic output, leading to T-cell exhaustion and immune dysregulation. Although B cells have been the main focus of the disorder, ample experimental data suggest that T-cell abnormalities can be seen in a large proportion of Freiburg Group 1a patients and those suffering from inflammatory complications. The reductions in T-cell receptor excision circles, naïve T cells, invariant NKT cells and regulatory T cells suggest a diminished thymic output, while CD8 T cells are driven towards exhaustion either via an antigen-dependent or an antigen-independent manner. The theoretical risk of anti-T-cell therapies is discussed, highlighting the need for an international effort in generating longitudinal data in addition to better-defined underlying molecular characterisation.
| Item Type: | Article |
|---|---|
| Subjects: | QZ Pathology. Oncology |
| Divisions: | Clinical Support > Pathology |
| Related URLs: | |
| Depositing User: | Mrs Yolande Brookes |
| Date Deposited: | 10 Feb 2017 09:38 |
| Last Modified: | 10 Feb 2017 09:38 |
| URI: | http://www.repository.uhblibrary.co.uk/id/eprint/1179 |
Actions (login required)
 |
View Item |
