Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.

Bryant, Josephine M, Grogono, Dorothy M, Rodriguez-Rincon, Daniela, Everall, Isobel, Brown, Karen P, Moreno, Pablo, Verma, Deepshikha, Hill, Emily, Drijkoningen, Judith, Gilligan, Peter, Esther, Charles R, Noone, Peadar G, Giddings, Olivia, Bell, Scott C, Thomson, Rachel, Wainwright, Claire E, Coulter, Chris, Pandey, Sushil, Wood, Michelle E, Stockwell, Rebecca E, Ramsay, Kay A, Sherrard, Laura J, Kidd, Timothy J, Jabbour, Nassib, Johnson, Graham R, Knibbs, Luke D, Morawska, Lidia, Sly, Peter D, Jones, Andrew, Bilton, Diana, Laurenson, Ian, Ruddy, Michael, Bourke, Stephen, Bowler, Ian C J W, Chapman, Stephen J, Clayton, Andrew, Cullen, Mairi, Dempsey, Owen, Denton, Miles, Desai, Maya, Drew, Richard J, Edenborough, Frank, Evans, Jason, Folb, Jonathan, Daniels, Thomas, Humphrey, Helen, Isalska, Barbara, Jensen-Fangel, Søren, Jönsson, Bodil, Jones, Andrew M, Katzenstein, Terese L, Lillebaek, Troels, MacGregor, Gordon, Mayell, Sarah, Millar, Michael, Modha, Deborah, Nash, Edward F, O'Brien, Christopher, O'Brien, Deirdre, Ohri, Chandra, Pao, Caroline S, Peckham, Daniel, Perrin, Felicity, Perry, Audrey, Pressler, Tania, Prtak, Laura, Qvist, Tavs, Robb, Ali, Rodgers, Helen, Schaffer, Kirsten, Shafi, Nadia, van Ingen, Jakko, Walshaw, Martin, Watson, Danie, West, Noreen, Whitehouse, Joanna L, Haworth, Charles S, Harris, Simon R, Ordway, Diane, Parkhill, Julian and Floto, R Andres (2016) Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science (New York, N.Y.), 354 (6313). pp. 751-757. ISSN 1095-9203.

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Official URL: http://science.sciencemag.org/content/354/6313/751...


Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

Item Type: Article
Subjects: WC Communicabable diseases > WC680 Tropical medicine
WF Respiratory system. Respiratory medicine
Divisions: Planned IP Care > Respiratory Medicine
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Depositing User: Preeti Puligari
Date Deposited: 30 Mar 2017 10:05
Last Modified: 30 Mar 2017 10:05
URI: http://www.repository.uhblibrary.co.uk/id/eprint/1299

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