Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial.

Forrester, Doug L, Knox, Alan J, Smyth, Alan R, Barr, Helen L, Simms, Rebecca, Pacey, Sarah J, Pavord, Ian D, Honeybourne, David, Dewar, Jane, Clayton, Andy and Fogarty, Andrew W (2016) Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial. Pediatric pulmonology, 51 (3). pp. 253-7. ISSN 1099-0496. This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ppul.23...

Abstract

RATIONALE

Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that oral glutamine supplementation (21 g/day) for 8 weeks in adults with cystic fibrosis would decrease pulmonary inflammation and improve clinical status.

METHODS

The study design was a randomized double-blind placebo-controlled study design with an iso-nitrogenous placebo. The primary analysis was intention to treat, and the primary outcome was change in induced sputum neutrophils.

RESULTS

Thirty-nine individuals were recruited and thirty-six completed the study. Glutamine supplementation had no impact on any of the outcome measures in the intention-to-treat analysis. In the per protocol analysis, glutamine supplementation was associated with an increase in induced sputum neutrophils (P = 0.046), total cells (P = 0.03), and in Pseudomonas isolation agar colony forming units (P = 0.04) compared to placebo.

CONCLUSIONS

There was no effect of glutamine supplementation on markers of pulmonary inflammation in the intention-to-treat analysis.

Item Type: Article
Additional Information: This article is available to all HEFT staff and students via ASK HEFT Discovery tool http://tinyurl.com/z795c8c using their HEFT Athens Login.
Subjects: WF Respiratory system. Respiratory medicine
Divisions: Planned IP Care > Respiratory Medicine
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Depositing User: Mr Philip O'Reilly
Date Deposited: 03 Apr 2017 11:33
Last Modified: 03 Apr 2017 11:33
URI: http://www.repository.uhblibrary.co.uk/id/eprint/1351

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