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Quraishi, M N, Critchlow, T, Bhala, N, Sharma, N and Iqbal, T (2017) Faecal transplantation for IBD management-pitfalls and promises. British medical bulletin. pp. 1-10. ISSN 1471-8391. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Full text not available from this repository.Abstract
Background
Faecal microbiota transplantation (FMT) as a potential treatment for inflammatory bowel disease (IBD) is an area of active current research, having been stimulated by the remarkable efficacy of FMT in treatment of Clostridium difficile-associated colitis.
Sources of data
This review is based on data from numerous case series on FMT in IBD since 1989 and results of four RCTs in ulcerative colitis (UC); three fully published.
Areas of agreement
Early signals of short to medium-term efficacy of FMT for UC are promising.
Areas of controversy
Methodology, underlying mechanisms and questions regarding safety of FMT remain controversial.
Growing points
Many trials of FMT in adults and children are currently recruiting.
Areas timely for developing research
Future trials of FMT will likely revisit Crohn's disease and patients undergoing pouch surgery. Advances in microbial culture complementing genetic sequencing and investigations into the virome and mycobiome in IBD will be of great future interest.
| Item Type: | Article |
|---|---|
| Additional Information: | This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs |
| Subjects: | WI Digestive system. Gastroenterology |
| Divisions: | Planned IP Care > Gastroentrology |
| Related URLs: | |
| Depositing User: | Miss Emily Johnson |
| Date Deposited: | 26 Jan 2018 13:40 |
| Last Modified: | 26 Jan 2018 13:40 |
| URI: | http://www.repository.uhblibrary.co.uk/id/eprint/1466 |
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