pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure.

McNamee, J J, Gillies, M A, Barrett, N A, Agus, A M, Beale, R, Bentley, A, Bodenham, A, Brett, S J, Brodie, D, Finney, S J, Gordon, A J, Griffiths, M, Harrison, D, Jackson, C, McDowell, C, McNally, C, Perkins, G D, Tunnicliffe, W, Vuylsteke, A, Walsh, T S, Wise, M P, Young, D and McAuley, D F (2017) pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure. Journal of the Intensive Care Society, 18 (2). pp. 159-169. ISSN 1751-1437.

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Official URL: http://journals.sagepub.com/doi/abs/10.1177/175114...

Abstract

One of the few interventions to demonstrate improved outcomes for acute hypoxaemic respiratory failure is reducing tidal volumes when using mechanical ventilation, often termed lung protective ventilation. Veno-venous extracorporeal carbon dioxide removal (vv-ECCO2R) can facilitate reducing tidal volumes. pRotective vEntilation with veno-venouS lung assisT (REST) is a randomised, allocation concealed, controlled, open, multicentre pragmatic trial to determine the clinical and cost-effectiveness of lower tidal volume mechanical ventilation facilitated by vv-ECCO2R in patients with acute hypoxaemic respiratory failure. Patients requiring intubation and mechanical ventilation for acute hypoxaemic respiratory failure will be randomly allocated to receive either vv-ECCO2R and lower tidal volume mechanical ventilation or standard care with stratification by recruitment centre. There is a need for a large randomised controlled trial to establish whether vv-ECCO2R in acute hypoxaemic respiratory failure can allow the use of a more protective lung ventilation strategy and is associated with improved patient outcomes.

Item Type: Article
Subjects: WF Respiratory system. Respiratory medicine
Divisions: Clinical Support > Critical Care
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Depositing User: Mrs Yolande Brookes
Date Deposited: 23 Nov 2017 15:22
Last Modified: 23 Nov 2017 15:22
URI: http://www.repository.uhblibrary.co.uk/id/eprint/1496

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