Reactivity of Routine HIV Antibody Tests in Children with Perinatally-Acquired HIV-1 in England: Cross Sectional Analysis.

Fidler, Katy, Foster, Caroline, Lim, Emma J, Patel, Amie, Welch, Steven B, Menson, Esse, Klein, Nigel and Judd, Ali (2018) Reactivity of Routine HIV Antibody Tests in Children with Perinatally-Acquired HIV-1 in England: Cross Sectional Analysis. The Pediatric infectious disease journal. ISSN 1532-0987. This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs

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Abstract

We assessed HIV antibody prevalence in children with perinatally-acquired HIV (PaHIV) in England. 18%(10/55) of those starting combination antiretroviral therapy (cART) <6 months of age were seronegative, and had lower viral load at diagnosis and cART start, and fewer viral rebounds, than 45/55 seropositives. Implications for patient selection for HIV cure research, and interpretation of routine antibody testing, are discussed.

Item Type:	Article
Additional Information:	This article is available to all HEFT staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their HEFT Athens login IDs
Subjects:	WD Diseases and disorders of systemic, metabolic or environmental origin > WD350 Immunologic diseases
Divisions:	Clinical Support > Infectious Diseases
Related URLs:	https://www.ncbi.nlm.nih.gov/pubmed/3019...
Depositing User:	Miss Emily Johnson
Date Deposited:	14 Sep 2018 12:53
Last Modified:	14 Sep 2018 12:53
URI:	http://www.repository.uhblibrary.co.uk/id/eprint/1739

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