Multi-ethnic genome-wide association study for atrial fibrillation.

Roselli, Carolina, Chaffin, Mark D, Weng, Lu-Chen, Aeschbacher, Stefanie, Ahlberg, Gustav, Albert, Christine M, Almgren, Peter, Alonso, Alvaro, Anderson, Christopher D, Aragam, Krishna G, Arking, Dan E, Barnard, John, Bartz, Traci M, Benjamin, Emelia J, Bihlmeyer, Nathan A, Bis, Joshua C, Bloom, Heather L, Boerwinkle, Eric, Bottinger, Erwin B, Brody, Jennifer A, Calkins, Hugh, Campbell, Archie, Cappola, Thomas P, Carlquist, John, Chasman, Daniel I, Chen, Lin Y, Chen, Yii-Der Ida, Choi, Eue-Keun, Choi, Seung Hoan, Christophersen, Ingrid E, Chung, Mina K, Cole, John W, Conen, David, Cook, James, Crijns, Harry J, Cutler, Michael J, Damrauer, Scott M, Daniels, Brian R, Darbar, Dawood, Delgado, Graciela, Denny, Joshua C, Dichgans, Martin, Dörr, Marcus, Dudink, Elton A, Dudley, Samuel C, Esa, Nada, Esko, Tonu, Eskola, Markku, Fatkin, Diane, Felix, Stephan B, Ford, Ian, Franco, Oscar H, Geelhoed, Bastiaan, Grewal, Raji P, Gudnason, Vilmundur, Guo, Xiuqing, Gupta, Namrata, Gustafsson, Stefan, Gutmann, Rebecca, Hamsten, Anders, Harris, Tamara B, Hayward, Caroline, Heckbert, Susan R, Hernesniemi, Jussi, Hocking, Lynne J, Hofman, Albert, Horimoto, Andrea R V R, Huang, Jie, Huang, Paul L, Huffman, Jennifer, Ingelsson, Erik, Ipek, Esra Gucuk, Ito, Kaoru, Jimenez-Conde, Jordi, Johnson, Renee, Jukema, J Wouter, Kääb, Stefan, Kähönen, Mika, Kamatani, Yoichiro, Kane, John P, Kastrati, Adnan, Kathiresan, Sekar, Katschnig-Winter, Petra, Kavousi, Maryam, Kessler, Thorsten, Kietselaer, Bas L, Kirchhof, Paulus, Kleber, Marcus E, Knight, Stacey, Krieger, Jose E, Kubo, Michiaki, Launer, Lenore J, Laurikka, Jari, Lehtimäki, Terho, Leineweber, Kirsten, Lemaitre, Rozenn N, Li, Man, Lim, Hong Euy, Lin, Henry J, Lin, Honghuang, Lind, Lars, Lindgren, Cecilia M, Lokki, Marja-Liisa, London, Barry, Loos, Ruth J F, Low, Siew-Kee, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Macfarlane, Peter W, Magnusson, Patrik K, Mahajan, Anubha, Malik, Rainer, Mansur, Alfredo J, Marcus, Gregory M, Margolin, Lauren, Margulies, Kenneth B, März, Winfried, McManus, David D, Melander, Olle, Mohanty, Sanghamitra, Montgomery, Jay A, Morley, Michael P, Morris, Andrew P, Müller-Nurasyid, Martina, Natale, Andrea, Nazarian, Saman, Neumann, Benjamin, Newton-Cheh, Christopher, Niemeijer, Maartje N, Nikus, Kjell, Nilsson, Peter, Noordam, Raymond, Oellers, Heidi, Olesen, Morten S, Orho-Melander, Marju, Padmanabhan, Sandosh, Pak, Hui-Nam, Paré, Guillaume, Pedersen, Nancy L, Pera, Joanna, Pereira, Alexandre, Porteous, David, Psaty, Bruce M, Pulit, Sara L, Pullinger, Clive R, Rader, Daniel J, Refsgaard, Lena, Ribasés, Marta, Ridker, Paul M, Rienstra, Michiel, Risch, Lorenz, Roden, Dan M, Rosand, Jonathan, Rosenberg, Michael A, Rost, Natalia, Rotter, Jerome I, Saba, Samir, Sandhu, Roopinder K, Schnabel, Renate B, Schramm, Katharina, Schunkert, Heribert, Schurman, Claudia, Scott, Stuart A, Seppälä, Ilkka, Shaffer, Christian, Shah, Svati, Shalaby, Alaa A, Shim, Jaemin, Shoemaker, M Benjamin, Siland, Joylene E, Sinisalo, Juha, Sinner, Moritz F, Slowik, Agnieszka, Smith, Albert V, Smith, Blair H, Smith, J Gustav, Smith, Jonathan D, Smith, Nicholas L, Soliman, Elsayed Z, Sotoodehnia, Nona, Stricker, Bruno H, Sun, Albert, Sun, Han, Svendsen, Jesper H, Tanaka, Toshihiro, Tanriverdi, Kahraman, Taylor, Kent D, Teder-Laving, Maris, Teumer, Alexander, Thériault, Sébastien, Trompet, Stella, Tucker, Nathan R, Tveit, Arnljot, Uitterlinden, Andre G, Van Der Harst, Pim, Van Gelder, Isabelle C, Van Wagoner, David R, Verweij, Niek, Vlachopoulou, Efthymia, Völker, Uwe, Wang, Biqi, Weeke, Peter E, Weijs, Bob, Weiss, Raul, Weiss, Stefan, Wells, Quinn S, Wiggins, Kerri L, Wong, Jorge A, Woo, Daniel, Worrall, Bradford B, Yang, Pil-Sung, Yao, Jie, Yoneda, Zachary T, Zeller, Tanja, Zeng, Lingyao, Lubitz, Steven A, Lunetta, Kathryn L and Ellinor, Patrick T (2018) Multi-ethnic genome-wide association study for atrial fibrillation. Nature genetics, 50 (9). pp. 1225-1233. ISSN 1546-1718. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://www.nature.com/articles/s41588-018-0133-9

Abstract

Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex heritability. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WG Cardiovascular system. Cardiology
Divisions: Emergency Services > Cardiology
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Depositing User: Mrs Semanti Chakraborty
Date Deposited: 19 Jul 2019 11:29
Last Modified: 19 Jul 2019 11:29
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2244

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