Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity.

Shetty, Shishir, Lalor, Patricia F and Adams, David H (2018) Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity. Nature reviews. Gastroenterology & hepatology, 15 (9). pp. 555-567. ISSN 1759-5053. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://www.nature.com/articles/s41575-018-0020-y

Abstract

Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do not simply form a barrier within the hepatic sinusoids but have vital physiological and immunological functions, including filtration, endocytosis, antigen presentation and leukocyte recruitment. Reflecting these multifunctional properties, LSECs display unique structural and phenotypic features that differentiate them from the capillary endothelium present within other organs. It is now clear that LSECs have a critical role in maintaining immune homeostasis within the liver and in mediating the immune response during acute and chronic liver injury. In this Review, we outline how LSECs influence the immune microenvironment within the liver and discuss their contribution to immune-mediated liver diseases and the complications of fibrosis and carcinogenesis.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WI Digestive system. Gastroenterology
Divisions: Planned IP Care > Gastroentrology
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Depositing User: Mrs Semanti Chakraborty
Date Deposited: 19 Jul 2019 11:52
Last Modified: 19 Jul 2019 11:52
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2245

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