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Richter, Alex G, Harding, Stephen, Huissoon, Aarnoud, Drayson, Mark and Pratt, Guy (2010) Multiple myeloma with monoclonal free IgG3 heavy chains and free kappa light chains. Acta Haematologica, 123 (3). pp. 158-61. ISSN 1421-9662.
Full text not available from this repository.Abstract
We describe the case of a 34-year-old gentleman investigated for persistent neutropaenia following two episodes of pneumonia. Specialist investigations led to the diagnosis of multiple myeloma (MM) producing a truncated monoclonal gamma(3) heavy chain (HC) immunoglobulin molecule unattached to a light chain (LC) with atypical features for both MM and HC disease. Western blot showed gamma(3)HC was truncated with a large deletion (75 kDa). Flow cytometry of the bone marrow aspirate revealed an unusual staining pattern. This plasma cell dyscrasia was also unusual in that a subpopulation (30%) secreted large quantities of free LC (FLC) as well as truncated IgG HC. This is the first description, investigation and treatment of MM with a plasma cell population producing truncated gamma(3)HC and kappaFLC M-proteins and illustrates a number of unique immunological and clinical features.
| Item Type: | Article |
|---|---|
| Subjects: | QW Microbiology. Immunology |
| Divisions: | Clinical Support > Pathology Emergency Services > Acute Medicine and AMU |
| Related URLs: | |
| Depositing User: | Preeti Puligari |
| Date Deposited: | 24 Jun 2014 15:07 |
| Last Modified: | 24 Jun 2014 15:07 |
| URI: | http://www.repository.uhblibrary.co.uk/id/eprint/230 |
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