Gavriilidis, Paschalis, Roberts, Keith J, de'Angelis, Nicola and Sutcliffe, Robert P (2019) Gastrectomy Alone or in Combination With Hepatic Resection in the Management of Liver Metastases From Gastric Cancer: A Systematic Review Using an Updated and Cumulative Meta-Analysis. Journal of clinical medicine research, 11 (8). pp. 600-608. ISSN 1918-3003. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
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Abstract
Background
Recent studies have demonstrated that hepatectomy in patients with synchronous hepatic gastric metastases may improve survival in certain patients. This study aimed to evaluate survival benefits of gastrectomy plus hepatectomy versus gastrectomy alone in patients with hepatic gastric metastases.
Methods
Studies were identified by a systematic search of Embase, PubMed, Cochrane Library, and Google Scholar databases. Traditional and cumulative meta-analyses were used to monitor the evidence over time.
Results
Eleven studies which included 861 patients compared gastrectomy plus hepatic resection in 349 patients with gastrectomy alone in 512 patients. Overall significantly better survival rates of 1, 2, 3, and 5 years were demonstrated for patients who underwent gastrectomy plus hepatic resection compared to patients who under underwent gastrectomy alone ((hazard ratio (HR) = 0.52 (0.39, 0.69), P < 0.001), (HR = 0.85 (0.74, 0.97), P = 0.01), (HR = 0.80 (0.72, 0.90), P = 0.003), (HR = 0.83 (0.78, 0.90), P < 0.001), respectively).
Conclusions
Carefully selected patients with hepatic gastric metastases may benefit from hepatic resection.
Item Type: | Article |
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Additional Information: | This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs |
Subjects: | WI Digestive system. Gastroenterology |
Divisions: | Planned IP Care > Gastroentrology |
Related URLs: | |
Depositing User: | Mrs Caroline Tranter |
Date Deposited: | 20 Aug 2019 11:06 |
Last Modified: | 20 Aug 2019 11:06 |
URI: | http://www.repository.uhblibrary.co.uk/id/eprint/2313 |
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