Practical Guidance for Measuring and Reporting Surgical Margins in Vulvar Cancer.

Kortekaas, Kim E, Van de Vijver, Koen K, van Poelgeest, Mariëtte I E, Gilks, C Blake, Smit, Vincent T H B M, Arif, Saimah, Arora, Deep, Faruqi, Asma, Ganesan, Raji, Griffin, Nicholas R, Hale, Richard, Hock, Yelin E, Horn, Lars-Christian, McCluggage, W Glenn, Mukonoweshuro, Pinias, Park, Kay J, Rous, Brian, Tanchel, Bruce, Van Rompuy, Anne-Sophie, van Schalkwyk, Gerry, Vella, Jo, Vergine, Marco, Singh, Naveena and Bosse, Tjalling (2019) Practical Guidance for Measuring and Reporting Surgical Margins in Vulvar Cancer. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. ISSN 1538-7151.

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Surgical resection with free surgical margins is the cornerstone of successful primary treatment of vulvar squamous cell carcinoma (VSCC). In general reexcision is recommended when the minimum peripheral surgical margin (MPSM) is <8 mm microscopically. Pathologists are, therefore, required to report the minimum distance from the tumor to the surgical margin. Currently, there are no guidelines on how to make this measurement, as this is often considered straightforward. However, during the 2018 Annual Meeting of the British Association of Gynaecological Pathologists (BAGP), a discussion on this topic revealed a variety of opinions with regard to reporting and method of measuring margin clearance in VSCC specimens. Given the need for uniformity and the lack of guidance in the literature, we initiated an online survey in order to deliver a consensus-based definition of peripheral surgical margins in VSCC resections. The survey included questions and representative diagrams of peripheral margin measurements. In total, 57 pathologists participated in this survey. On the basis of consensus results, we propose to define MPSM in VSCC as the minimum distance from the peripheral edge of the invasive tumor nests toward the inked peripheral surgical margin reported in millimeters. This MPSM measurement should run through tissue and preferably be measured in a straight line. Along with MPSM, other relevant measurements such as depth of invasion or tumor thickness and distance to deep margins should be reported. This manuscript provides guidance to the practicing pathologist in measuring MPSM in VSCC resection specimens, in order to promote uniformity in measuring and reporting.

Item Type: Article
Subjects: QZ Pathology. Oncology
WP Gynaecology. Women’s health
Divisions: Clinical Support > Pathology
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Depositing User: Mrs Yolande Brookes
Date Deposited: 30 Aug 2019 14:50
Last Modified: 30 Aug 2019 14:50

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