Review article: impact of exercise on physical frailty in patients with chronic liver disease.

Williams, Felicity R, Berzigotti, Annalisa, Lord, Janet M, Lai, Jennifer C and Armstrong, Matthew J (2019) Review article: impact of exercise on physical frailty in patients with chronic liver disease. Alimentary pharmacology & therapeutics. ISSN 1365-2036. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://onlinelibrary.wiley.com/doi/full/10.1111/a...

Abstract

BACKGROUND

Physical frailty is common in chronic liver disease and the setting of liver transplantation. It is associated with poor quality of life, increased hospitalisation and mortality. Despite this, the impact of exercise in these patients remains poorly understood.

AIM

To summarise the impact of physical exercise on physical frailty in patients with chronic liver disease until after liver transplantation.

METHODS

A MEDLINE and PubMed search was undertaken using the terms; "physical activity", "functional capacity", "exercise", "prehabilitation", "frailty", "liver cirrhosis", "liver failure", "liver transplantation" "chronic liver disease" and "end-stage liver disease" from January 1990 to June 2019.

RESULTS

Eleven studies (five randomised controlled, five observational, one case study) demonstrated that exercise improves VO peak, anaerobic threshold, 6-minute walk distance, muscle mass/function and quality of life in patients with compensated and decompensated cirrhosis. Improvements were most significant with a combination of aerobic and resistance exercises at moderate-high intensity. The studies were small (n = 1-50) and mainly focused on supervised, hospital-based exercises, excluding patients with significant liver failure (MELD > 12). Seven studies (four randomised controlled and three observational) demonstrated that predominantly supervised (only one home-based) aerobic exercise after liver transplantation improves aerobic capacity, muscle mass/strength and quality of life. There was marked heterogeneity in timing, intensity and type of exercises.

CONCLUSION

Exercise improves key components of physical frailty (functional/aerobic capacity, sarcopenia) and quality of life in chronic liver disease and after liver transplantation. Understanding the type, compliance, intensity and duration of exercise and its impact on hard clinical outcomes should be the focus of future large controlled clinical trials.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WB Practice of medicine > WB450 Rehabilitation
WI Digestive system. Gastroenterology
Divisions: Emergency Services > Therapies
Planned IP Care > Gastroentrology
Related URLs:
Depositing User: Beth Connors
Date Deposited: 16 Sep 2019 14:01
Last Modified: 16 Sep 2019 14:01
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2395

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