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Khalil, Khalid, Bansal, Sukhchain, Ayaani, Soofiyah, Hodson, James, Lam, For Tai, Khan, Saboor, Ahmad, Jawad, Isaac, John R, Muiesan, Paolo, Mirza, Darius F, Dasari, Bobby, Marudanayagam, Ravi, Sutcliffe, Robert P, Marangoni, Gabriele and Roberts, Keith J (2018) Does blood group affect survival following pancreatoduodenectomy for periampullary malignancy? HPB : the official journal of the International Hepato Pancreato Biliary Association, 20 (9). pp. 848-853. ISSN 1477-2574. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Full text not available from this repository.Abstract
BACKGROUND
Blood group is reported to have an effect upon survival following pancreatoduodenectomy for pancreatic ductal adenocarcinoma. The effect of blood group is not known, however, among patients with other periampullary cancers. This study sought to review this.
METHODS
Data were collected for a range of factors and survival outcomes from patients treated at two centres. Those with blood groups B and AB were excluded, due to small numbers. Patient survival was compared between patients with blood groups O and A using multivariable analysis which accounted for confounding factors.
RESULTS
Among 431 patients, 235 (54.5%) and 196 (45.5%) were of blood groups A and O respectively. Baseline comparisons found a significant difference in the distribution of tumour types (p = 0.011), with blood group O patients having more ampullary carcinomas (33.2% vs 23.4%) and less pancreatic ductal adenocarcinomas (45.4 vs 61.3%) than group A. On multivariable analysis, after accounting for confounding factors including pathologic variables, survival was found to be significantly shorter in those with blood group A than group O (p = 0.047, HR 1.30 [95%CI: 1.00-1.69]).
CONCLUSIONS
There is a difference in the distribution of blood groups across the different types of periampullary cancers. Survival is shorter among blood group A patients.
| Item Type: | Article |
|---|---|
| Additional Information: | This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs |
| Subjects: | WI Digestive system. Gastroenterology |
| Divisions: | Planned IP Care > Gastroentrology |
| Related URLs: | |
| Depositing User: | Jamie Edgar |
| Date Deposited: | 23 Sep 2019 10:56 |
| Last Modified: | 28 Jan 2021 15:58 |
| URI: | http://www.repository.uhblibrary.co.uk/id/eprint/2401 |
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