Re-examining Permissive Hypercapnia in ARDS: A Narrative Review.

Barnes, Tavish, Zochios, Vasileios and Parhar, Ken (2018) Re-examining Permissive Hypercapnia in ARDS: A Narrative Review. Chest, 154 (1). pp. 185-195. ISSN 1931-3543.

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Lung-protective ventilation (LPV) has become the cornerstone of management in patients with ARDS. A subset of patients is unable to tolerate LPV without significant CO elevation. In these patients, permissive hypercapnia is used. Although thought to be benign, it is becoming increasingly evident that elevated CO levels have significant physiological effects. In this narrative review, we highlight clinically relevant end-organ effects in both animal models and clinical studies. We also explore the association between elevated CO, acute cor pulmonale, and ICU mortality. We conclude with a brief review of alternative therapies for CO management currently under investigation in patients with moderate to severe ARDS.

Item Type: Article
Subjects: WB Practice of medicine > WB400 Intensive care
Divisions: Emergency Services > Acute Medicine and AMU
Related URLs:
Depositing User: Jennifer Manders
Date Deposited: 27 Sep 2019 14:30
Last Modified: 27 Sep 2019 14:30

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