Impact of menopause on outcomes in prolactinomas after dopamine agonist treatment withdrawal.

Santharam, Sandhya, Fountas, Athanasios, Tampourlou, Metaxia, Arlt, Wiebke, Ayuk, John, Gittoes, Neil, Toogood, Andrew and Karavitaki, Niki (2018) Impact of menopause on outcomes in prolactinomas after dopamine agonist treatment withdrawal. Clinical endocrinology, 89 (3). pp. 346-353. ISSN 1365-2265. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/ce...

Abstract

OBJECTIVE

Discontinuation of dopamine agonist (DA) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long-term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group.

DESIGN/PATIENTS

Retrospective cohort study of women with prolactinoma diagnosed before menopause and who after menopause were not on DA.

RESULTS

Thirty women were included. Twenty-eight received DA (median duration 18 years, median age at DA withdrawal 52 years). At last assessment (median follow-up 3 years) and compared with values 6-12 months after stopping DA, Prolactin (PRL) increased in 15%, decreased but not normalized in 33% and was normal in 52%; PRL levels or visible adenoma on imaging before DA withdrawal, treatment duration and presence of macro-/microadenoma at diagnosis were not predictors of normoprolactinaemia at last review, whereas PRL values 6-12 months after stopping DA were. Adenoma regrowth was detected in 2/27 patients (7%), who showed gradual increase in PRL. Comparison with 28 women who had DA withdrawal before their menopause revealed lower risk of hyperprolactinaemia recurrence in the postmenopausal group (HR:0.316, 95% CI: 0.101-0.985, P < .05). Two women with microprolactinoma diagnosed in perimenopausal period had not been offered DA; PRL decreased (but not normalized) during observation of 1 and 8 years.

CONCLUSIONS

Prolactin normalized over time in nearly half of the women and serum PRL 6-12 months after DA withdrawal is useful predictor. Nonetheless, 7% of the patients demonstrated adenoma regrowth which, given the life expectancy postmenopause, necessitate regular monitoring of the cases with persistent hyperprolactinaemia.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WK Endocrine system. Endocrinology
WP Gynaecology. Women’s health
Divisions: Ambulatory Care
Related URLs:
Depositing User: Jennifer Manders
Date Deposited: 26 Nov 2019 12:53
Last Modified: 26 Nov 2019 12:53
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2620

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