Sarcopenia in Non-alcoholic Fatty Liver Disease: New challenges for clinical practice.

El Sherif, Omar, Dhaliwal, Amritpal, Newsome, Philip N and Armstrong, Matthew J (2020) Sarcopenia in Non-alcoholic Fatty Liver Disease: New challenges for clinical practice. Expert review of gastroenterology & hepatology. ISSN 1747-4132.

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: Sarcopenia is increasingly recognised in patients with non-alcoholic liver disease (NAFLD). Initially recognised as a consequence of advanced liver disease, there is now emerging evidence that sarcopenia may be a novel risk factor for the development of NAFLD, with a role in fibrosis and disease progression.: This review examines the epidemiology, pathogenesis and complex interplay between NAFLD and sarcopenia. Furthermore, the authors discuss the challenges with diagnosis of sarcopenia in the clinic and the evidence-based management of sarcopenia in patients with NAFLD. A MEDLINE and PubMed search was undertaken using the terms; "sarcopenia", "frailty", "muscle", "obesity", "non-alcoholic fatty liver disease", "non-alcoholic steatohepatitis" and "cirrhosis" up to 31 September 2019.: Sarcopenia may be masked by the co-existence of morbid obesity, which is most notable in patients with NAFLD. Sarcopenia is a key indicator of adverse outcomes in patients with cirrhosis, such as hepatic decompensation, poor quality of life and premature mortality. Patients with NAFLD and advanced fibrosis/cirrhosis should undergo anthropometric measures (hand grip strength), dry body mass index and measures of physical frailty (including muscle function, not just mass) to enable targeted early interventions of nutrition (low fat, 1.5g/kg/day protein intake, 2-3 hourly food intake) and exercise (combined resistance and aerobic).

Item Type: Article
Subjects: QU Biochemistry
WI Digestive system. Gastroenterology
Divisions: Planned IP Care > Gastroentrology
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Depositing User: Mr Muneeb Liaquat
Date Deposited: 21 Feb 2020 14:28
Last Modified: 21 Feb 2020 14:28

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