Elevated Serum Free Light Chains Predict Cardiovascular Events in Type 2 Diabetes.

Bellary, Srikanth, Faint, Jeffrey M, Assi, Lakhvir K, Hutchison, Colin A, Harding, Stephen J, Raymond, Neil T and Barnett, Anthony H (2014) Elevated Serum Free Light Chains Predict Cardiovascular Events in Type 2 Diabetes. Diabetes care. ISSN 1935-5548.

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OBJECTIVEElevated polyclonal serum immunoglobulin free light chains (FLCs; combined FLCκ+FLCλ [cFLC]) are associated with adverse clinical outcomes and increased mortality; we investigated cFLC and cardiovascular disease (CVD) events in type 2 diabetes.RESEARCH DESIGN AND METHODSIn a cohort study of 352 south Asian patients with type 2 diabetes, serum cFLC, high-sensitivity C-reactive protein (hsCRP), and standard biochemistry were measured. CVD events over 2 years were recorded and assessed using multiple logistic regression.RESULTScFLC levels were elevated significantly in 29 of 352 (8%) patients with CVD events during 2 years follow-up (50.7 vs. 42.8 mg/L; P = 0.004). In multivariate analysis, elevated cFLC (>57.2 mg/L) was associated with CVD outcomes (odds ratio 3.3 [95% CI 1.3-8.2]; P = 0.012) and remained significant after adjusting for age, albumin-to-creatinine ratio, diabetes duration, or treatment.CONCLUSIONScFLC elevation is a novel marker for CVD outcomes in type 2 diabetes that warrants further investigation.

Item Type: Article
Subjects: WK Endocrine system. Endocrinology
Divisions: Ambulatory Care > Diabetes
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Depositing User: Users 7 not found.
Date Deposited: 20 Jun 2014 09:06
Last Modified: 20 Jun 2014 09:06
URI: http://www.repository.uhblibrary.co.uk/id/eprint/289

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